If there's one thing that Bubbles loves even more than defending Townsville from evildoers, it's the cartoon llama from her favorite TV show - you know, the one that spits magical fruit flavors for children and adults to enjoy! Bubbles loves that llama so much, in fact, that she wishes with all her might for it to become real - and danged if her wish doesn't come true!
Life with an actual fruit-spitting llama is everything that Bubbles could have hoped for, but unfortunately the rest of the now-spit-soaked city doesn't agree - in fact, it soon becomes all too clear that the Powerpuff Girls must figure out a way to reverse Bubbles' wish before all of Townsville is buried under deadly saliva-drenched fruits!