Merging with a bizarre spiritual force called Genesis, Texan preacher Jesse Custer possesses the power of "the word," an ability to make people do whatever he commands. Custer embarks on a violent and riotous journey across the country, joined by his gun-toting girlfriend Tulip and the hard-drinking Irish vampire Cassidy, witnessing dark atrocities and improbable calamities during his sojourn across America. Collects Preacher #1-33, Preacher Special: Saint of Killers #1-4, and Preacher Special: Cassidy-Blood & Whiskey #1.